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Sangyep Shin, Ph.D.

Postdoctoral Research Fellow

Laboratory of Neural Circuits and Behavior
Program in Neuroscience
801 W. Baltimore Street
Suite 301
Baltimore, MD 21201
443-860-2580 ext.
syshin@hussmanautism.org

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  • Education & Experience
  • Research Background
  • Research Interests
  • Selected Publications

Education & Experience

2018-present   Postdoctoral Research Fellow, Hussman Institute for Autism (Baltimore, MD)

2017-2018       Postdoctoral Research Fellow, Eulji University (Daejeon, South Korea)

2017                Ph.D. Physiology and Biophysics, Eulji University (Daejeon, South Korea)

2012                B.S. Biomedical Laboratory Science, Eulji University (Daejeon, South Korea)

Research Background

During my Ph.D. study, I used several animal models of neurodevelopmental and psychiatric conditions, including depression, anxiety, autism and ADHD. Employing behavioral tests and electrophysiological recording, I examined synaptic plasticity and excitation/inhibition balance in hippocampus and striatum of these animal models. The main goal of my studies was to investigate the mechanisms or relationship between behavioral phenotypes and electrophysiological results. In my doctoral dissertation, I revealed that reduced synaptic plasticity in the DG-CA3 area of the ventral hippocampus correlated with increased anxiety and aggression in neonatal maternal separation animal models. I also discovered that increased GABAergic activity in granule cells of DG may result in the reduction of synaptic plasticity exhibited in these animals.

Research Interests

My interest lies in how gene mutations lead to alternation of behaviors, changes of neural connectivity and disruption of neural activity in genetically modified animal models. In autism spectrum disorders, there are many different symptoms, and these symptoms are heterogeneous among individuals. I believe that genetic animal models provide a powerful tool for us to study autism. Therefore, I am interested in examining the underpinnings of changes in neural circuits and synaptic imbalance in autism using combination of genetic animal models and electrophysiological methods.

Selected Publications

Shin SY, Han SH, Woo RS, Jang SH, Min SS. Adolescent mice show anxiety- and aggressive-like behavior and the reduction of long-term potentiation in mossy fiber-CA3 synapses after neonatal maternal separation. Neuroscience 2016, 316:221-31. (PMID: 26733385)

 

Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee JY, Kim C and Min SS. Phorbol 12-Myristate 13-Acetate enhances long-term potentiation in the hippocampus through activation of protein kinase Cδ and ε. Korean J Physiol Pharmacol 2013, 17(1):51-56. (PMID: 23440225)

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  • “In the end, the best argument for inclusion is the simplest. It’s the one we know by heart – that all of us are created equal.”

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Recent Activity:
  • Supporting Students with Special Needs: Online Training Modules for School-Based Professionals who Support Students with Disabilities
    April 16, 2019
  • Parental optimism, school inclusion may affect long-term progress of individuals with autism
    April 12, 2016
  • Young adults with autism increase empathic communication with training
    March 24, 2016
  • Seeing things differently: Altered GABA signaling at play in autistic visual perception
    March 10, 2016

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Administration & Program on Autism Supports
Hussman Institute for Autism
6021 University Blvd, Ste 490
Ellicott City, MD 21043
Phone 443-860-2580 | Email info@hussmanautism.org

Program on Neuroscience
Hussman Institute for Autism
801 W. Baltimore Street, Third Floor
Baltimore, MD 21201
Phone 443-860-2580 | Email info@hussmanautism.org

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